Stop-cystitis for the treatment of urological diseases in cats

The main thing for a caring owner is a healthy and cheerful pet. If suddenly your pet has difficulty going to the toilet and does not allow you to touch his hard, ball-like tummy, then you should quickly contact a veterinarian. These are signs of cystitis in a cat. Many pets are susceptible to this disease; it mainly occurs in cats. A unique new generation remedy, Stop Cystitis, will help relieve inflammation, pain, and speed up the process of complete recovery.

Composition of the drug

Stop-cystitis is a combination drug. It contains not only chemically created components, but also herbs. One milliliter of medication contains the following types of components:

• Nitroxaline – 12.5 mg. It helps fight various pathogens of urinary tract diseases and is active against both fungi and bacteria.
• Drotaverine hydrochloride – 6 mg. Helps not only relieve spasms and relax smooth muscles, but also relieve pain.

Another type of components are medicinal plants that help fight microbes, relieve inflammation and spasms:

• Extracts of nettle leaves – 5 mg.
• Extracts of lingonberry leaves – 5 mg.
• Licorice root extract – 5 mg.
• Knotweed herb extracts – 5 mg.
• Juniper fruit extracts – 5 mg.

Stop-Cystitis tablets

Instructions for the use of Stop-cystitis tablets for the treatment and prevention of inflammatory and infectious diseases of the urinary tract and urolithiasis in cats and dogs (organization - developer: API-SAN LLC, Moscow)

I. General information Trade name of the medicinal product: Stop-cystitis® tablets (Stop-cystitis tabulettae). International nonproprietary name: nitroxoline, drotaverine, knotweed extract, nettle leaf extract, birch leaf extract, horsetail herb extract, lingonberry leaf extract, licorice root extract. Dosage form: tablets for oral use.

Stop-cystitis tablets are available in two modifications:

In appearance, the drug is a round tablet, covered with a green coating.

Stop-cystitis tablets are produced in 15 or 20 pieces, packaged in polymer jars, sealed with plastic lids with first opening control. Cans are packed individually in cardboard boxes. Each packaging unit is accompanied by instructions for use.

Store the drug in the manufacturer's sealed packaging, separate from food and feed, in a dry place, protected from direct sunlight, at a temperature from minus 10°C to 25°C. The shelf life of Stop-cystitis tablets, subject to storage conditions in the manufacturer's closed packaging, is 3 years from the date of production. Do not use Stop Cystitis tablets after the expiration date.

Tablets should be kept out of the reach of children.

Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties Stop-cystitis tablets belong to the group of combined antimicrobial drugs. They have antimicrobial, anti-inflammatory, antispasmodic, diuretic and saluretic effects. Nitroxoline , which is part of the drug, is a derivative of 8-hydroxyquinoline, is active against a wide range of gram-positive, gram-negative bacteria and some fungi that cause urinary tract infections, including Staphylococcus spp., Ureaplasma urealyticum, Corynebacterium spp., Escherichia coli, Salmonella spp. After oral administration, it is quickly absorbed from the gastrointestinal tract. It is excreted unchanged by the kidneys. High concentrations of nigroxoline are detected in the urine. Drotaverine hydrochloride has a long-lasting antispasmodic, myotropic and vasodilating effect, eliminates spasms of smooth muscles of the urinary tract and bladder tenesmus. The maximum concentration in the blood serum after oral administration is recorded at 45-60 minutes. Metabolism of the drug occurs in the liver. Biological half-life is 16-22 hours. Within 72 hours, it is practically eliminated from the body, approximately 30% in urine, and 50% in feces. It is mainly excreted in the form of metabolites and is not detected unchanged in the urine. The complex of biologically active components of medicinal plants (flavonoids, essential oils, tannins, vitamins, mineral compounds) has antiseptic, diuretic, antispasmodic and anti-inflammatory properties, and promotes the removal of stones in urolithiasis.

Stop-cystitis tablets, in terms of the degree of impact on the body, are classified as low-hazard substances (hazard class 4 according to GOST 12.1.07-76); in recommended doses, the drug does not have a local irritant or sensitizing effect.

III. Directions for use Stop-cystitis tablets are prescribed to dogs and cats for the treatment and prevention of acute and chronic inflammatory and infectious diseases of the urinary tract (cystitis, pyelonephritis, urethritis) and urolithiasis, prevention of infections after diagnostic procedures and in the postoperative period after removal of urinary stones.

Contraindications for use are acute heart and liver failure, increased individual sensitivity of the animal to the components of the drug. Pregnant and lactating animals should use the drug after consultation with the attending veterinarian.

Stop-cystitis tablets are administered to animals individually with food or administered directly to the root of the tongue for therapeutic purposes twice a day, for prophylactic purposes - once a day for 5-7 days, in the following doses:

The duration of the course of use of the drug is determined by the attending veterinarian depending on the physiological state of the animal and the course of the disease.

No overdose symptoms have been identified in animals.

When using the drug for the first time, the animal may experience profuse drooling.

You should avoid missing the next dose of the drug, as this may lead to a decrease in its effectiveness. If one dose is missed, the use of the drug is resumed at the same dosage and according to the same regimen.

As a rule, there are no side effects or complications when using the drug in accordance with these instructions. If the animal has increased individual sensitivity to the components of the drug and allergic reactions occur, the use of Stop-cystitis tablets should be discontinued.

The drug is compatible with other medications, feed and feed additives.

Stop-cystitis tablets are not intended for use in productive animals.

Pharmacology

Stop cystitis for cats has a wide spectrum of action:

• Nitroxaline is the active substance that is included in its composition. It has an antimicrobial effect. Nitroxaline is effective against the following microbial and fungal pathogens: staphylococci, streptococci, salmonella, enterococci, candida.
• Another active substance, drotaverine hydrochloride, removes spasms, relaxes smooth muscles, dilates blood vessels, and reduces blood pressure. Drotaverine hydrochloride reduces increased vascular tone by reducing the flow of calcium into the muscle cell of the body. Because of this, pain during urination in cats decreases.
• Thanks to the plants included in its composition, stop cystitis has antimicrobial, diuretic and antispasmodic effects. Medicinal plants help remove small stones and toxins from the genitourinary system of cats.
• Extracts from plants that make up the medicine include saponins, flavonoids, vitamins, essential oils, mineral components and tannins. This is good for the regenerative function of the kidneys and urinary tract. It also has a beneficial effect on the sexual function of pets.

Stop-cystitis for cats is well absorbed in the animal’s stomach and is easily tolerated by adults, pregnant cats and small kittens. It can also be used as a prophylactic for cats prone to urological diseases.

Contraindications

As already noted, if the indicated dosage and recommendations of the treating veterinarian are strictly followed, no side effects are observed in cats after taking the veterinary drug. In case of individual intolerance, hypersensitivity to the active components of the drug, allergic reactions may occur, and salivation may be profuse. In this case, contact your veterinarian, stop taking the drug, and give the cat an antihistamine.

Stop-cystitis is not recommended for treatment and prevention in animals with chronic heart or kidney failure.

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Indications for use of the drug

Stop cystitis is widely used to treat diseases such as:

• Cystitis.
• Pyelonephritis.
• Urethritis.
• Urolithiasis disease.
• As a prophylactic agent used for diseases of the kidneys and urinary tract.

In addition, stop cystitis is often used before procedures such as:

• Cystoscopy.
• Catheterization for diagnosis.
• Carrying out planned operations on the bladder, kidneys, and ureters.

Profitable loyalty

There is an objective anatomical reason for the fact that cystitis is predominantly female. After all, in the fair sex, the urethra is much shorter and wider than the male one, so the path upward to the bladder for pathogenic microbes becomes shorter and easier. However, for a disease to occur, the penetration of microbial agents alone is not enough. After all, the protective forces of the bladder mucosa, guarded by beneficial lacto- and bifidobacteria, are usually sufficient to give a worthy rebuff to the infection. But if local immunity is weakened, then it’s a different matter. The protective forces of the mucous membrane can be negatively affected, for example, by hypothermia, injury, stress, excessive alcohol intake, promiscuous sex life, poor intimate hygiene, chronic diseases, etc.

By the way, frequent changes of sexual partners for women (and especially young girls with unsettled hormonal levels and not fully formed intimate microflora) are even more harmful than for men. And we’re not just talking about sexually transmitted diseases. After all, the female intimate flora is forced to adapt to the partner’s flora each time (after all, men’s intimate organs normally contain streptococci and other opportunistic flora). At some point, the adaptation process may be disrupted, and then the female microflora will suffer, and against this background, candidiasis, cystitis, and other troubles may arise. Therefore, it is especially important for girls to remain faithful to their only sexual partners, and it is better for very young ladies not to rush into “adult” life.

Contraindications and side effects of the drug

This medicine is related to low-hazard substances. It was assigned the fourth hazard class. It is quite easily tolerated by animals. Instructions for use describe the following negative aspects when using the medicine:

• Individual intolerance.
• An allergic reaction may occur to any component of the drug because the tablets contain a large amount of herbs. When using the medicine for the first time, you need to observe your pet. If a pronounced allergic reaction occurs, the cat should be given antihistamines.
• The drug is contraindicated in cats suffering from acute heart failure.
• It is not recommended for use by animals with pathological changes in the kidneys.
• It should not be used without the advice of a veterinarian for preventive purposes, since it is possible to reduce pronounced symptoms if the condition of the organ worsens.
• Caution should be exercised when using the drug in pregnant cats.

Along the beaten track

Judging by statistics, every second woman after the first episode of the disease develops a relapse within a year. And half of them have exacerbations more than 3 times a year. This happens because the initial treatment of acute cystitis was incorrect, and also because, when faced with a new case of the disease, many women, out of habit, take the medicine that helped them the last time. This is a huge mistake! The class of antibiotic must be changed, otherwise harmful bacteria, a small part of which could remain in the bladder, will develop resistance to the drug, and this will lead to the drug no longer working, and cystitis itself becoming chronic.

Therefore, a good doctor, before prescribing an antibacterial medicine, will definitely ask the patient how long ago and what kind of antibiotic he recently took.

BY THE WAY

In the West, cystitis is an inflammatory disease of the bladder and urethra. And in Russia, the disease is divided into cystitis and urethritis. In the first case we are talking about inflammation of the bladder, in the second – about inflammation of the urethra. And although these are details, we will adhere to the domestic view of the disease.

Release form and dosage

Stop cystitis is available in two forms - suspension and tablets:

1. The suspension is sold in dosed bottles of 30, 50, 100, 150 ml. The drug in this form is presented in the form of a viscous mixture, light brown or dark green in color, with a pleasant taste. Along with the suspension, a measuring cup and syringe are available to accurately determine the dosage of the drug.
2. Tablets of 200 mg are packaged in jars of 15 pieces each.

Instructions for use recommend the following dosage of the drug:

Suspension:

• If the animal's weight is less than 5 kg, then it is recommended to give 2 ml 2 times a day.
• If the weight is more than 5 kg, then use 3 ml 2 times a day.

Pills:

• If you weigh less than 5 kg, take 1 tablet 2 times a day.
• If you weigh more than 5 kg, take 2 tablets 2 times a day.

Only a veterinarian can calculate the exact dose of the drug; it depends on the age, condition and weight of the cat.

Unless directed by a veterinarian, use of the drug should not exceed 7 days with an interval of 2 months.

Analogs and price

The cost of Stop Cystitis medicine is on average 250 rubles. per pack of 15 tablets. If uroseptic is not available in the veterinary pharmacy, it can be replaced with another medication with a similar effect.

The drug Stop Cystitis for cats does not have many analogues on the market. The most popular substitutes are:

• KotErvin - contains only plant components. Shows the best therapeutic effect only as part of complex therapy. Available in drops. It has similar indications as Stop Cystitis. The price of 3 bottles of 10 ml per package is 180 rubles.
• Urolex - contains only phytocomponents, therefore it is not prohibited for pregnant and lactating females. The cost of a 20 ml bottle is 200 rubles.
• Nephrocat is a plant-based tablet for the treatment of urinary tract infections. The phytocomposition differs from the drug Stop-cystitis, but contains no less effective natural uroseptics. The cost of packaging (15 pcs.) is 300 rubles.
• Stop Cystitis Bio is an analogue of the tablet form. Contains the same plant components, but does not include nitroxoline and drotaverine. Produced in the form of a suspension. The price of a 50 ml bottle is 340 rubles.

Site Expert

Alexandra Maksimovna Palagina

Education: Moscow State Academy of Veterinary Medicine and Biotechnology named after. K.I. Scriabin, Faculty of Veterinary Medicine, specialty – veterinarian

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