Purevax is a vaccine developed to protect cats
Feline vaccines PUREVAX series
help protect cats against a range of diseases, including rabies (R), feline leukemia virus (FeLV), panleukopenia and pathogens that commonly cause feline respiratory disease (CPCH). The Purevax line of feline vaccines induces an effective immune response without the use of adjuvants, which may pose a potential risk to cats for post-injection sarcoma.
Purevax is intended for the prevention of infections in cats and kittens - without the use of adjuvants. An adjuvant is a substance that is added to a vaccine to enhance the cat's immune response to the vaccine. Adjuvants have been associated with injection site reaction, injection site granuloma, and chronic inflammation in cats. Cases have been described when chronic inflammatory edema in cats after injections degenerates into a tumor. The Purevax vaccine has a minimal risk of developing such complications.
Vaccines for cats Purevax are the optimal solution in terms of preventing infectious complications in cats:
"CoviVac"
The drug became the third Russian vaccine against coronavirus; it was created at the Chumakov Center in Moscow.
CoviVac contains the SARS-CoV-2 virus itself. But this virus cannot infect humans, since it is inactivated and is not able to reproduce in the human body. The same technology is used for the production of the polio vaccine.
Who can I bet on?
The drug is suitable for vaccination of people from 18 to 60 years of age. CoviVac has not yet completed phase 3 clinical trials. After it, the effect of the vaccine on patients over 60 years of age will become known. The tests will be completed in June.
At the same time, trials will be conducted for people with cancer and autoimmune diseases, as well as chronic obstructive pulmonary disease.
Contraindications for vaccination
CoviVac, like the other two vaccines, cannot be used for severe forms of allergies in a patient. In case of exacerbation of chronic diseases, vaccination should also not be given. It will be necessary to delay vaccination due to acute infectious or other diseases.
The drug is contraindicated in people who have seizures or fevers, or who have had an acute reaction to other vaccines.
Interval between vaccinations
CoviVac consists of two components. For full protection, you need to get two vaccinations. Unlike Sputnik V, EpiVacCorona, the interval between drug administration is much shorter and is 14 days instead of 21.
When will antibodies appear?
Accurate information will be available after the third phase of clinical trials.
Purevax vaccine profile
According to the instructions, PUREVAX® is a one-of-a-kind range of vaccines against feline infections that does not contain adjuvants.
Optimized safety profile with effective protection against infection, without adjuvants for all components; Powerful immune response without adjuvant thanks to innovative technology for FeLV and rabies; Easily accommodates all cat lifestyles, allowing compliance with cat vaccination regulations; Sustained protection against rabies for up to three years.
- Name and trademark Purevax®
- Active ingredients against feline herpes virus
- Feline calicivirus (C)
- Feline panleukopenia virus (P)
- Chlamydophila felis (C)
- recombinant vector feline leukemia virus (FeLV)
- recombinant vector rabies virus (R)
Purevax rcpch - complex vaccine for cats
Purevax rcpch is a vaccine against rabies, feline viral rhinotracheitis, feline calicivirus, feline panleukopenia and feline chlamydophilic infections.
This is a summary of the European Public Assessment Report. Its purpose is to explain how the Committee for Veterinary Medicinal Products (CVMP) assessment, based on the documentation provided, led to recommendations for conditions of use.
This article cannot replace a face-to-face discussion with your veterinarian. If you need more information about your animal's health or treatment, please contact your veterinarian. If you want more information based on the CVMP recommendations, read the scientific discussion (also part of the EPAR).
Use of the drug for kittens and pregnant cats
We need to think about disease prevention from an early age. The kitten's immunity is weak, viral diseases can be deadly for them. It is allowed to vaccinate a kitten with Purevax from the age of eight weeks.
A kitten can be vaccinated from the age of two months.
Pregnant and lactating cats are not vaccinated with this product.
What is Purevax RCPCh?
Purevax RCPCh is a veterinary vaccine that contains:
- weakened (attenuated) feline rhinotracheitis herpesvirus (strain FHV F2),
- inactivated (killed) calicivirus antigens (FCV strains 431 and G1),
- attenuated Chlamydophila felis (strain 905),
- attenuated panleukopenia virus in cats (PLI IV).
Purevax RCPCh is available in the form of a lyophilisate (lyophilized granules) and a solvent, which are converted into an injection suspension.
What is Purevax RCPCh used for in cats?
Purevax RCPCh is used to vaccinate cats from 8 weeks of age
from the following diseases:
- feline viral rhinotracheitis (influenza-like illness caused by a herpes virus),
- feline calicivirus (influenza-like disease with inflammation of the tongue and mouth caused by calicivirus),
- feline chlamydia (influenza-like disease caused by the bacterium C. felis),
- feline panleukopenia (a serious disease causing bloody diarrhea caused by parvovirus, called feline distemper).
The Purevax vaccine helps reduce the symptoms of diseases, prevent the occurrence of an infectious process and significantly increase the safety and survival of kittens. Purevax vaccination also helps reduce viral excretion in case of calicivirus infection for one year after vaccination. The vaccine also prevents deaths from panleukopenia.
According to the instructions for use, the Purevax vaccine is administered in the form of two consecutive doses injected under the skin. The first injection should be given to kittens at least eight weeks old, and the second injection three to four weeks later. If the kitten has high levels of antibodies acquired from the mother cat in utero or through milk, the first vaccination should be delayed until 12 weeks of age. The cat should be revaccinated for all components one year after the first course of vaccination, then every year for chlamydia and every three years for rhinotracheitis, calicivirus and panleukopenia.
special instructions
If a vaccine bottle does not have a label, is not sealed or sealed, has changed color or consistency, has been frozen, contains foreign matter, or has not been used within twenty minutes of dilution, it is not can be used for its intended purpose, it must be disinfected by boiling for five to ten minutes and disposed of. The simultaneous use of Purevax and Rabizin vaccines is permissible if they are administered separately. Other drugs can be used with a break of at least two weeks before or after using Purevax.
How does the Purevax RCPCh vaccine work?
Purevax RCPCh is the top vaccine for cats. Vaccines work by “teaching” the cat’s immune system (the cat’s natural defenses) how to protect itself from disease. Purevax RCPCh contains small amounts of weakened or killed viruses and bacteria that commonly cause feline rhinotracheitis, calicivirus, chlamydia and panleukopenia.
When a cat is given a vaccine, the immune system recognizes weakened or killed viruses and weakened bacteria as “foreign” and produces antibodies against them. In the future, the immune system will be able to produce its own antibodies more quickly when it is again exposed to the same viruses or bacteria. Antibodies will help protect against illnesses caused by these viruses or bacteria. If exposed to any of these viruses later in life, the cat will either not become infected or will have a much less severe infection.
Indications for use
Purevax vaccines are prescribed to healthy animals to form active immunity against viruses. First of all, cats walking outside are at risk of infectious infections. But pets also need to be regularly vaccinated: the fact is that the infection can be carried on shoes and outerwear, and there is also a risk of infection through dirty water, poorly processed food, soil in flower pots, etc. You should not take risks, since diseases against which Purevax protects, are deadly and difficult to treat (for example, death from plague occurs in 90% of cases). It is better to worry in advance about protecting your animals from viruses.
A cat that sits at home all the time is not completely protected from viruses, so it also needs vaccination
Video: cat vaccination
How the drug works
The cat is given an injection with the drug Purevax, which contains weakened strains of viruses. They are incapable of causing disease, but when the vaccine enters the body, the immune system carefully “studies” its protein structure and begins to produce special agents (antibodies) to destroy the “enemy.” After 12–20 days, all biocomponents of Purevax are destroyed, and the immune system remembers the way to destroy such infections for about a year. If during this time the cat becomes infected with the virus, the immune system will be prepared and will quickly be able to cope with the disease. After a year, the vaccination procedure should be repeated.
How was Purevax RCPCh developed and studied?
The effectiveness of Purevax RCPCh has been studied in several in vitro and clinical trials where cats were vaccinated and challenged with herpesvirus, calicivirus, C. felis, or parvovirus. Field studies of the effectiveness of the Purevax RCPCh vaccine looked at a primary vaccination schedule (2 injections 3-4 weeks apart) and booster vaccination. Among them were young and adult cats of various breeds, but not young kittens. The main indicator of effectiveness was the level of antibodies in the blood against the viruses and bacteria in the vaccine.
Possible side effects and contraindications
In addition to pregnancy, feeding kittens and under 8 months of age, Purevax is prohibited for animals with any acute or chronic diseases. You should not vaccinate weakened animals with underweight. If the cat has recently been ill, then you need to wait two weeks and only then get vaccinated.
Despite the good tolerability of the drug, in some cases Purevax can cause side effects:
- lethargy;
- nausea;
Nausea is one of the side effects of the vaccine
- vomiting;
- diarrhea.
After 3-4 days, these symptoms should subside. There may be a slight increase in temperature on the first day. If the “side effects” last longer than the specified period and steadily increase, you should immediately take the cat to the veterinarian. These are either signs of an allergic reaction to the drug, or the vaccination was given to a sick animal and its immune system cannot cope with the load.
What effect did the Purevax RCPCh vaccination show during clinical trials?
Purevax RCPCh has been shown in vitro to provide protection against the diseases listed above. In field studies of basic vaccination, increases in antibodies against feline rhinotracheitis herpesvirus, calicivirus infection, and feline panleukopenia viruses were observed. It was not possible to detect an increase in antibodies against C. felis due to high antibody levels in the cats at baseline. In the booster study, antibody levels against herpes rhinotracheitis virus, calicivirus infection, feline panleukopenia, and C. felis remained stable at high levels or increased slightly.
What are the risks associated with Purevax RCPCh vaccination in cats?
Sometimes cats develop temporary apathy after vaccination with Purevax.
(loss of interest in the environment) and anorexia (loss of appetite), as well as hyperthermia (increased body temperature) lasting for one or two days. There may be a local reaction at the injection site with slight pain to the touch, itching or swelling (swelling), which disappears within one or two weeks. For a complete list of side effects reported with Purevax RCPCh, see the instructions for use.
Purevax RCPCh vaccine should not be used in pregnant cats.
Reviews about vaccination
I have been vaccinating cats with Purevax since it appeared in Russia. The shelter where I work is vaccinated with the same drug. I love this vaccine dearly because of the absence of complications, which I have never observed.
vet_life
https://ru-vet.livejournal.com/4248449.html
I vaccinated the kitten with Purevax, no side effects. Our vet uses it and praises it very much.
Matilda
https://forum.mau.ru/viewtopic.php?t=59730
There were no complaints about the tolerability of the Purevax vaccination itself, everything went completely unnoticed, I vaccinated at 8 weeks and revaccinated at 12. This vaccine is my choice.
Svetlana (Thai cat)
https://www.thaicat.ru/forum/8–385–3
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